Fingering instability in spreading epithelial monolayers: roles of cell polarisation, substrate friction and contractile stresses

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چکیده

Numerical simulations and linear stability analyses of expanding cellular monolayers suggest cell–substrate friction is responsible for fingers at the edge. A critical contractile stress characterises wetting-dewetting; dewetting inhibits fingering.

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ژورنال

عنوان ژورنال: Soft Matter

سال: 2021

ISSN: ['1744-683X', '1744-6848']

DOI: https://doi.org/10.1039/d1sm00626f